Molecular Profiling of Pancreatic Cancer Patients—Response

Integrative survival-based molecular profiling of human pancreatic cancer.

PURPOSE To carry out an integrative profile of human pancreatic ductal adenocarcinoma (PDAC) to identify prognosis-significant genes and their related pathways. EXPERIMENTAL DESIGN A concordant survival-based whole genome in silico array analysis of DNA copy number, and mRNA and miRNA expression in 25 early-stage PDAC was carried out. A novel composite score simultaneously integrated gene exp...

Molecular profiling of pancreatic adenocarcinoma and chronic pancreatitis identifies multiple genes differentially regulated in pancreatic cancer.

The molecular basis of pancreatic cancer is not understood. Previous attempts to determine the specific genes expressed in pancreatic cancer have been hampered by similarities between adenocarcinoma and chronic pancreatitis. In the current study, microarrays (Affymetrix) were used to profile gene expression in pancreatic adenocarcinoma (10), pancreatic cancer cell lines (7), chronic pancreatiti...

NMR-based Metabolite Profiling of Pancreatic Cancer

Metabolite profiles of serum from pancreatic cancer (PC) patients (n=51) and non-disease controls (n=47) were measured using H nuclear magnetic resonance (NMR) spectroscopy with a focus on the metabolic changes associated with PC pathology and the development and external validation of the statistical models developed using the metabolite data. Univariate statistical analysis indicated 42 metab...

Molecular Profiling of Breast Cancer

Evidence for the Importance of Personalized Molecular Profiling in Pancreatic Cancer

OBJECTIVES There is a growing body of evidence that targeted gene therapy holds great promise for the future treatment of cancer. A crucial step in this therapy is the accurate identification of appropriate candidate genes/pathways for targeted treatment. One approach is to identify variant genes/pathways that are significantly enriched in groups of afflicted individuals relative to control sub...